Review: Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair

摘要: Brain and spinal cord injury can result in permanent cognitive, motor, sensory autonomic deficits. The central nervous system (CNS) has a poor intrinsic capacity for regeneration, although some functional recovery does occur. This is mainly the form of sprouting, dendritic remodelling changes neuronal coding, firing synaptic properties; elements collectively known as plasticity. An important approach to repair injured CNS therefore harness, promote refine In adult, this partly limited by extracellular matrix (ECM). While ECM typically provides supportive framework neurones, its role not only structural; homeostatic, actively regulatory great signalling importance, both directly via receptor or coreceptor-mediated action spatially temporally relevant localization other molecules. an disease state, represents key environment support healing and/or regenerative response. However, there are aspects composition which prove suboptimal recovery: molecules present restrict plasticity limit repair. therapeutic concept render more permissive manipulating components, such inhibitory chondroitin sulphate proteoglycans. review we discuss major components they play during development following brain consider number experimental strategies involve manipulations ECM, with aim promoting cord.