Tuberculosis, bacillus Calmette-Guérin vaccination, and allergic disease: Findings from the International Study of Asthma and Allergies in Childhood Phase Two

摘要: Some have suggested a protective effect of tuberculosis (TB) infection on allergic disease risk, but few studies examined the association between two. We therefore investigated whether TB and bacillus Calmette-Guerin (BCG) vaccination in early life protect against disease. Information symptoms, past disease, BCG as well potential confounding factors was gathered by parental questionnaire from randomly selected subset 23,901 8- to 12-yr-old schoolchildren 20 centers both developed developing countries. Children were also physically for flexural eczema underwent skin prick testing. Pooled odds ratio (OR) estimates corresponding 95% confidence intervals (CIs) across study calculated, using random effects meta-analysis models. There 245 (1.0%) reported cases 66.3% (15,857) all children received vaccine. Asthma, hay fever, symptoms year examination positively linked history (adjusted pooled OR 'wheeze year' = 2.27, CI 1.52-3.41; adjusted 'hay fever 2.23, 1.22-4.09; 'flexural 3.21, 2.01-5.12; examination' 4.04, 1.71-9.56). Even higher risk seen severe asthma [adjusted 4.02 (2.17-7.47) 6.31 (2.19-18.17), respectively]. no significant test positivity 1.32, 0.87-2.02). during first not associated with any allergy outcomes. found uniform positive outcomes, including examination. As this cross-sectional study, it is unclear attributable causal relationship, further longitudinal are required.