beta-Carbolines, psychoactive compounds in the mammalian body. Part II: Effects.

摘要: The biochemical and the pharmacological effects of beta-carbolines in animals man are reviewed. Biochemical studies have revealed beta-carbolines' several actions, including inhibition MAO-A, competitive 5-HT uptake, general Na+ dependent transports, binding to benzodiazepine opiate receptors probable action on dopamine receptors, which may all participate a variable degree actions different beta-carbolines. Many early vivo studies, however, concentrated some harmala alkaloids, particularly harmaline or harmine. compared this review with symptoms alcohol withdrawal. However, no human been reported those tetrahydro-beta-carbolines shown occur body normal conditions after intake. To prove any connections withdrawal syndromes other neurological psychiatric diseases means that these compounds be abnormal central nervous system concentrations diseases. physiological role has yet shown. They act as neuromodulators some, especially 6-methoxytetrahydro-beta-carboline, an endocrinological function. It suggested ligands (agonists) but so far known seem effects, such MAO-A uptake low concentrations.