Genetic association between NFKB1 -94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies.

摘要: Accumulating evidences have indicated that the functional -94 ins/del ATTG polymorphism in promoter region of human nuclear factor-kappa B1 (NFKB1) gene may be associated with cancer risk. However, some studies yielded conflicting results. To clarify precise association, we performed a comprehensive meta-analysis 42 case-control involving 43,000 subjects (18,222 cases and 24,778 controls). The overall results suggested had decreased risk for cancer, reaching significant levels five genetic models (dominant model: OR = 0.86, 95% CI = 0.79-0.95, P = 0.002; recessive OR = 0.84, CI = 0.74-0.94, P = 0.003; homozygous OR = 0.77, CI = 0.66-0.90, P = 0.001; heterozygous OR = 0.90, CI = 0.83-0.98, P = 0.011; allelic OR = 0.89, CI = 0.83-0.96, P = 0.002). Furthermore, could confer or increased development among Asians Caucasians, respectively. Additionally, stratification analysis revealed association between variant oral, ovarian, nasopharyngeal Asians. After adjusted p values using Benjamini-Hochberg false discovery rate method to account multiple comparisons, these associations remained.