Drug-induced hepatic disorders. Incidence, management and avoidance.

摘要: Drug-induced liver injury has been associated with more than 800 different drugs, leading to hospital admission in 1 of 600 3500 admissions. This amounts 2 3% all hospitalisations due adverse drug reactions, or about jaundiced patients. The prognosis clinically overt hepatotoxicity is relatively serious. clinical picture essentially nonspecific, a highly variable latency period from days years. Drug can mimic almost any kind disease. A thorough history, low threshold suspicion and the exclusion other causes disease are important for detection drug-induced disorders.