Intensive cholesterol lowering with statin improves the outcomes of percutaneous coronary intervention in patients with acute coronary syndrome.

摘要: BACKGROUND The incidence of no reflow phenomenon limits the clinical outcomes percutaneous coronary intervention (PCI). This randomized controlled study was designed to evaluate immediate protective effects intensive statin pretreatment on myocardial perfusion and ischemic injury during PCI. METHODS Altogether 228 patients with acute syndrome (ACS) were randomly assigned standard group (SS group, n = 115) (IS 113). Patients in SS received 20 mg simvastatin IS 80 for 7 days before Thrombolysis infarction (TIMI) flow grade (TFG), corrected TIMI frame count (CTFC) (TMPG) intervened vessel recorded after stent deployment. Creatine kinase (CK) isoenzyme MB, troponin I plasma level high sensitive-C reactive protein (hs-CRP), P-selectin intercellular adhesion molecule (ICAM) measured 24 hours procedure. RESULTS TFG deployment significantly improved less 0-1 more 3 blood than (all P < 0.05). (P 0.001). CTFC lower TMPG also Although PCI caused a significant increase CK-MB procedure, elevated value (18.74 +/- 8.41 vs 21.78 10.64, 0.018). Similar changes found (0.99 1.07 1.47 1.54 0.006). elevation occurred 27.8% (32/115) 15.9% (18/113) 0.030). Myocardial necrosis detected 4.4% (5/115) whereas 0.9% (1/113) 0.341). But found. Similarly, increased much (36.5%, 42/115) (19.5%, 22/113) 0.04). Among them, 13.0% (15/115) while (5/113) 0.021). 0.213). CONCLUSIONS Intensive can further improve perfusion, protect myocardium from injury. These are associated lowered levels hs-CRP, ICAM.