Differential pathlength factor informs evoked stimulus response in a mouse model of Alzheimer's disease.
作者： Alexander J. Lin , Adrien Ponticorvo , Anthony J. Durkin , Vasan Venugopalan , Bernard Choi
关键词:
摘要: Baseline optical properties are typically assumed in calculating the differential pathlength factor (DPF) of mouse brains, a value used modified Beer-Lambert law to characterize an evoked stimulus response. We spatial frequency domain imaging measure vivo baseline 20-month-old control ([Formula: see text]) and triple transgenic APP/PS1/tau (3xTg-AD) brains. Average [Formula: text] for 3xTg-AD mice was text], respectively, at 460 nm; 530 nm. The calculated DPF OD mm, In hindpaw stimulation experiments, hemodynamic increase brain tissue concentration oxyhemoglobin threefold larger two times longer compared mice. Furthermore, washout deoxyhemoglobin from increased perfusion seven controls text]).
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