ABCB5-ZEB1 Axis Promotes Invasion and Metastasis in Breast Cancer Cells.
作者： Juntao Yao , Xuan Yao , Tao Tian , Xiao Fu , Wenjuan Wang
DOI: 10.3727/096504016X14734149559061
关键词:
摘要: ABCB5 belongs to the ATP-binding cassette (ABC) superfamily, which is recognized for playing a role in failure of chemotherapy. has also been found be overexpressed at transcriptional level number cancer subtypes, including breast cancer. However, exact mechanism uses on cell metastasis still unclear. In present study, we demonstrate that expression was increased metastatic tissues when compared with nonmetastatic tissues. can significantly enhance and epithelial-mesenchymal transition (EMT), while knockdown inhibited these processes. Microarray analysis indicated ZEB1 may function as downstream factor ABCB5. Furthermore, positively relevant Knocking down inhibits ectopic expression-induced migration invasion, well EMT. Taken together, results helped realize oncogene functions cells provided new direction treating
sci-hub.se 参考文章(22)
Franz X. Bosch, Claudia Andl, Ulrich Abel, Jürgen Kartenbeck, E-cadherin is a selective and strongly dominant prognostic factor in squamous cell carcinoma: a comparison of E-cadherin with desmosomal components. International Journal of Cancer. ,vol. 114, pp. 779- 790 ,(2005) , 10.1002/IJC.20782
S Kuphal, A K Bosserhoff, Influence of the cytoplasmic domain of E-cadherin on endogenous N-cadherin expression in malignant melanoma. Oncogene. ,vol. 25, pp. 248- 259 ,(2006) , 10.1038/SJ.ONC.1209054
Justin M. Drake, J. Matthew Barnes, Joshua M. Madsen, Frederick E. Domann, Christopher S. Stipp, Michael D. Henry, ZEB1 coordinately regulates laminin-332 and β4 integrin expression altering the invasive phenotype of prostate cancer cells Journal of Biological Chemistry. ,vol. 285, pp. 33940- 33948 ,(2010) , 10.1074/JBC.M110.136044
Shumin Zhang, Xu Wang, Shareen Iqbal, Yanru Wang, Adeboye O Osunkoya, Zhengjia Chen, Zhuo Chen, Dong M Shin, Hongwei Yuan, Yongqiang A Wang, Haiyen E Zhau, Leland WK Chung, Chad Ritenour, Omer Kucuk, Daqing Wu, None, Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition Journal of Biological Chemistry. ,vol. 288, pp. 1469- 1479 ,(2013) , 10.1074/JBC.M112.438341
E Sánchez-Tilló, A Lázaro, R Torrent, M Cuatrecasas, E C Vaquero, A Castells, P Engel, A Postigo, ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. Oncogene. ,vol. 29, pp. 3490- 3500 ,(2010) , 10.1038/ONC.2010.102
Brian J Wilson, Tobias Schatton, Qian Zhan, Martin Gasser, Jie Ma, Karim R Saab, Robin Schanche, Ana-Maria Waaga-Gasser, Jason S Gold, Qin Huang, George F Murphy, Markus H Frank, Natasha Y Frank, None, ABCB5 Identifies a Therapy-Refractory Tumor Cell Population in Colorectal Cancer Patients Cancer Research. ,vol. 71, pp. 5307- 5316 ,(2011) , 10.1158/0008-5472.CAN-11-0221
Yan Wang, Yongfeng Shang, Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis. Experimental Cell Research. ,vol. 319, pp. 160- 169 ,(2013) , 10.1016/J.YEXCR.2012.07.019
Yibin Kang, Joan Massagué, Epithelial-mesenchymal transitions: twist in development and metastasis. Cell. ,vol. 118, pp. 277- 279 ,(2004) , 10.1016/J.CELL.2004.07.011
Bruce R Ksander, Paraskevi E Kolovou, Brian J Wilson, Karim R Saab, Qin Guo, Jie Ma, Sean P McGuire, Meredith S Gregory, William JB Vincent, Victor L Perez, Fernando Cruz-Guilloty, Winston WY Kao, Mindy K Call, Budd A Tucker, Qian Zhan, George F Murphy, Kira L Lathrop, Clemens Alt, Luke J Mortensen, Charles P Lin, James D Zieske, Markus H Frank, Natasha Y Frank, None, ABCB5 is a limbal stem cell gene required for corneal development and repair Nature. ,vol. 511, pp. 353- 357 ,(2014) , 10.1038/NATURE13426
Idoia G. Zubeldia, Anne-Marie Bleau, Miriam Redrado, Diego Serrano, Alice Agliano, Carmen Gil-Puig, Fernando Vidal-Vanaclocha, Jon Lecanda, Alfonso Calvo, Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFβ1-targeting peptides P17 and P144 Experimental Cell Research. ,vol. 319, pp. 12- 22 ,(2013) , 10.1016/J.YEXCR.2012.11.004