Animal Models of Hepadnavirus Associated Hepatocellular Carcinoma

摘要: Animal models of hepatitis B virus infection have been valuable for determining the mechanisms hepadnavirus replication, studies pathogenesis, and investigations viral hepatocarcinogenesis. The woodchuck model also seems to be useful in discovery development antiviral drugs treat HBV testing new forms immunotherapy. In particular, ideal studying effect treatment immunotherapy on outcome survival. median life expectancy experimentally infected, chronic WHV carriers is approximately 29 months, almost all develop HCC. New types prophylaxis or therapy can evaluated under controlled experimental conditions, a relevant animal model, within reasonable time frame.