Perioperative Patient Reported Outcomes Predict Serious Postoperative Complications: A Secondary Analysis of the COST Trial

摘要: Decreased survival after colon cancer surgery has been reported in patients with deficient preoperative quality of life. We hypothesized that deficits life are associated postoperative complications. A secondary analysis the Clinical Outcomes Surgical Therapy trial NCCTG 93-46-53 (INT 0146, Alliance) was performed. Quality deficit defined as overall score <50 on a 100-point scale and used for univariate multivariate analysis. Of 431 enrolled portion trial, 81 (19 %) experienced complications including two deaths (0.5 %). Fifty-five (13 %) had <50. Patients were more likely to have serious early complication (16 vs 6 %, p = 0.023). Using stepwise logistic model, variables significantly having any (yes/no) age, ASA III change “activity” from baseline day 14. an 3.5-day longer hospital stay (p = 0.0001). Gender, race, tumor stage, laparoscopic or open approach not increased frequency After adjusting demographics, ASA, operative approach, significant predictors readmission pain (odds ratio (OR) 1.61, confidence interval (CI) 1.11–2.34, p = 0.0125), changes 2 fatigue (OR 1.34, CI 1.03–1.74, p = 0.032). This study suggests can provide indicator at risk Further studies should evaluate how perioperative assessment may assist improve outcomes.