Effect of insulin on the synthesis of glycogen in cerebral cortical slices of alloxan diabetic rats.

摘要: Synthesis of glycogen in cerebral cortical slices alloxan diabetic rats could not be demonstrated with glucose as the substrate. Intravenous administration insulin gave rise to synthesis these same Addition medium also produced a striking such slices. Slices cortex ofdiabetic synthesized presence 5 DIM sodium pyruvate and mM acetate, while normal did not. Glucose-6- phosphatase activity rat, which is 1/5 that liver, reduced almost insignificant levels condition. {Endocrinology 82: 1, 1968)