Nodal promotes aggressive phenotype via Snail-mediated epithelial-mesenchymal transition in murine melanoma.
作者： Rui Fang , Ge Zhang , Qiang Guo , Fen Ning , Hao Wang
DOI: 10.1016/J.CANLET.2013.01.014
关键词:
摘要: Abstract Nodal, an important embryonic morphogen, has been reported to function in tumorigenesis. Here we report for the first time that Nodal promotes malignancy by inducing epithelial–mesenchymal transition (EMT) B16 murine melanoma. These cells displayed increased migration and invasion abilities upon treating with accompanying typical phenotype changes of EMT. In contrast, knockdown or blocking signaling using a specific antagonist SB431542 repressed EMT as well reduced cell motility invasiveness. Treatment also induced expression transcription factor Snail. Snail abolished Nodal-induced cells. We further show is mediated Nodal-regulated AKT/GSK-3β signaling. Taken together, these results revealed aggressive melanoma via up-regulation This study provides better understanding melanoma, suggests potential novel target clinical therapeutic research.
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