Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells

摘要: Human monocyte-derived interleukin 1 (IL-1) was found to be a potent inducer of procoagulant activity in cultured human vascular endothelium. IL-1-induced umbilical vein endothelial cell (HEC-PCA) transiently expressed, manifest intact monolayers, and required protein synthesis. Data obtained with coagulation factor-deficient plasma goat anti-human apoprotein III antiserum suggested that most, if not all, is tissue factor-like. IL-1 induction HEC-PCA may important the pathogenesis intravascular variety immunological inflammatory conditions.