Mucosal Restitution and Repair
作者： D. Brent Polk , Mark R. Frey
DOI: 10.1016/B978-0-12-382026-6.00042-7
关键词:
摘要: The mammalian intestinal epithelium serves as a critical barrier between the organism and contents of gut, providing for regulated uptake food fluid well protection from pathogens toxins. As this single-cell lining is constantly subjected to insult injury, efficient cell migration, restitution, repair responses have evolved ensure remains intact. Failure or dysregulation these processes implicated in number disease states, including inflammatory bowel diseases colorectal cancer. Thus, thorough understanding regulatory mechanisms promoting limiting wound-healing response gut will open new therapeutic avenues gastrointestinal diseases. This chapter discuss basic migration involved laboratory methods used investigate process, current knowledge molecular by which regulates wound healing small intestine colon.
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