α-l-Iduronidase forms semi-crystalline spherulites with amyloid-like properties
作者： Laura Ruth , David Eisenberg , Elizabeth F. Neufeld
DOI: 10.1107/S090744490000007X
关键词:
摘要: While seeking conditions for single crystals of human α-l-iduronidase, solutions were discovered (pH 3.0–8.5 containing calcium or zinc salts) that transform soluble α-l-iduronidase to a solid aggregate. This aggregate is spherulite semi-crystalline protein. The X-ray diffraction pattern and ability bind Congo red characterize the as `amyloid-like', in it displays two characteristics amyloidogenic proteins. In addition, also interacts with heparin, do some amyloid-forming
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