Is intragenic recombination a factor in the maintenance of genetic variation in natural populations

摘要: INTRAGENIC recombination between two different existing alleles in a population can create new alleles. The role of this process maintaining variation natural has been investigated1 by assuming that gene consists sites, each which mutate to an infinite number unique ‘alleles’ (the allele model Kimura and Crow2). Using it was shown if the product size, N, mutation rate, μ, is ⩾1, r, same order magnitude as then intragenic significantly increases maintained finite population. Moreover, not equivalent increase rate variance homozygosity are larger. This implies sampling theory neutral developed Ewens3 does apply situation where important variation4. Application these results study populations would require large independent samples estimate However, data from usually consist their frequencies single sample. Therefore, for effect be observable, there must detectable change distribution sample contains k We present here Monte Carlo simulation show equilibrium frequency most common allele, occur only once sample, homozygosity.