Pediatric epilepsy syndromes.

摘要: The development of an international classification for epilepsies and epileptic syndromes has led to substantial progress in the understanding treatment patients with epilepsy. Epilepsies are partitioned first by seizure type then etiology. This manuscript describes recent advances six major pediatric epilepsy syndromes. three discussed (benign childhood centrotemporal spikes, juvenile myoclonic epilepsy, absence epilepsy) most common syndromes, each been focus significant research. Patients benign spikes rolandic may not require anticonvulsant therapy, their seizures always remit midadolescence. Juvenile was syndrome which a gene locus found. underlying neuronal pathways cellular mechanisms generalized well delineated. last (West syndrome, Lennox-Gastaut acquired aphasia) devastating catastrophic research West (infantile spasms) develop better therapeutic interventions (both medical surgical) improved its pathogenesis. New effective medications available (childhood encephalopathy), but one them (felbamate) associated previously unrecognized serious side effects. Lastly, aphasia is example poorly understood syndrome. A multicenter group organized reexamine this produce pathogenesis treatment.