Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury

摘要: Xenon-induced neuroprotection has been well studied both in vivo and vitro. In this study, the neuroprotective properties of other noble gases, namely, krypton, argon, neon helium, were explored an vitro model neuronal injury. Pure cultures, derived from foetal BALB/c mice cortices, provoked into injury by oxygen glucose deprivation (OGD). Cultures exposed to either nitrogen hypoxia or gas balanced salt solution devoid for 90 min. The cultures allowed recover normal culture medium a further 24 h gas. effect gases on cell reducing ability absence OGD was also investigated. Cell quantified via MTT assay expressed as ratio control. caused reduction 0.56 ± 0.04 control (p < 0.001). Like xenon (0.92 0.10; p 0.001), afforded argon (0.71 0.05; 0.01). Neon krypton did not have protective under our experimental conditions. Helium had detrimental cells. OGD, reduced uninjured cells 0.84 0.09 0.01), but showed improvement 1.15 0.11 0.05). Our data suggest that cheap widely available may potential neuroprotectant future.