Inhibition of visceral pain by electrical stimulation of the periaqueductal gray matter.

作者: Glenn J. Giesler , John C. Liebeskind

DOI: 10.1016/0304-3959(76)90045-2

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摘要: Abstract Numerous recent studies have demonstrated that electrical stimulation of the periaqueductal gray matter (PGM) can result in powerful analgesia to pain somatic origin. In present study, we developed a visceral test employing intraperitoneal injection hypertonic saline which yields writhing response adult rat more reliably than other painproducing substances. With this show as well radiant heat (tail flick test) are completely inhibited all animals with PGM electrode placements.

参考文章(23)
Louis J. Pellegrino, Anna J. Cushman, A stereotaxic atlas of the rat brain Published in <b>1967</b> in New York NY) by Appleton-Century-Crofts. ,(1967)
Michael Selzer, W. Alden Spencer, Convergence of visceral and cutaneous afferent pathways in the lumbar spinal cord Brain Research. ,vol. 14, pp. 331- 348 ,(1969) , 10.1016/0006-8993(69)90114-0
Huda Akil, David J. Mayer, Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor Brain Research. ,vol. 44, pp. 692- 697 ,(1972) , 10.1016/0006-8993(72)90338-1
P. D. Wall, The laminar organization of dorsal horn and effects of descending impulses. The Journal of Physiology. ,vol. 188, pp. 403- 423 ,(1967) , 10.1113/JPHYSIOL.1967.SP008146
H. O. J. COLLIER, C. SCHNEIDER, Profiles of Activity in Rodents of Some Narcotic and Narcotic Antagonist Drugs Nature. ,vol. 224, pp. 610- 612 ,(1969) , 10.1038/224610A0
M.B. Hancock, R.D. Foreman, W.D. Willis, Convergence of visceral and cutaneous input onto spinothalamic tract cells in the thoracic spinal cord of the cat. Experimental Neurology. ,vol. 47, pp. 240- 248 ,(1975) , 10.1016/0014-4886(75)90253-8
John C. Liebeskind, David J. Mayer, Somatosensory evoked responses in the mesencephalic central gray matter of the rat Brain Research. ,vol. 27, pp. 133- 151 ,(1971) , 10.1016/0006-8993(71)90376-3
P. Hillman, P.D. Wall, Inhibitory and excitatory factors influencing the receptive fields of lamina 5 spinal cord cells. Experimental Brain Research. ,vol. 9, pp. 284- 306 ,(1969) , 10.1007/BF00235240
Donald P. Becker, Henry Gluck, Frank E. Nulsen, John A. Jane, An Inquiry into the Neurophysiological Basis for Pain Journal of Neurosurgery. ,vol. 30, pp. 1- 13 ,(1969) , 10.3171/JNS.1969.30.1.0001
D. J. Mayer, T. L. Wolfle, H. Akil, B. Carder, J. C. Liebeskind, Analgesia from Electrical Stimulation in the Brainstem of the Rat Science. ,vol. 174, pp. 1351- 1354 ,(1971) , 10.1126/SCIENCE.174.4016.1351