Reversibility of the inhibition of acetylcholinesterase by tacrine
作者： Raymond M. Dawson
DOI: 10.1016/0304-3940(90)90254-7
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摘要: Inhibition of bovine erythrocyte acetylcholinesterase (AChE) by 1,2,3,4-tetrahydro-9-acridinamine (tacrine) was independent time incubation and partially reversed dilution increased substrate concentration. It fully dialysis. Similar results were obtained with AChE from other sources. The are consistent some reports in the literature, but not others; none these examined all four criteria reversibility. do explain prolonged inhibition vivo or ability tacrine to protect animals against lethal effects organophosphate anticholinesterases.
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