Neurochemical Aspects of Ischemic Injury

摘要: The brain has the highest metabolic rate of all organs and depends predominantly on oxidative metabolism as a source energy. Thus, it utilizes about 20% respired oxygen for normal function, even though represents only 5% body weight. Much taken up by neurons is utilized producing ATP, which needed not maintaining appropriate ionic gradients across neural membranes but also creating proper cellular redox potentials. Full transient deficits in glucose can rapidly compromise ATP production threaten integrity either or abnormally modulating ion homeostasis redox. initial response to insufficiency energy depolarization resulting Na+ influx into axons.