ASYMMETRIC TOTAL SYNTHESIS OF INDOLMYCIN
作者： Takeshi Takeda , Teruaki Mukaiyama
DOI: 10.1246/CL.1980.163
关键词:
摘要: An asymmetric total synthesis of indolmycin was achieved via a key intermediate, α-indolmycenic acid ester. The ester obtained by oxygenation methyl (S)-3-(3-indolyl)butanoate which prepared utilizing (2R,3S)-3,4-dimethyl-2-phenylperhydro-l,4-oxazepine-5,7-dione. (2S,3R)-N-[2-Hydroxy-3-(3-indolyl)-butanoyl]-N′-methylthiourea from treated with 2-chlorobenzoxazolium salt to give in 93% optical purity.
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