Dimensions of emotionality in a rat model of innate anxiety.
作者： Frauke Ohl , N. Toschi , A. Wigger , M. S. H. Henniger , R. Landgraf
DOI: 10.1037/0735-7044.115.2.429
关键词:
摘要: Emotionality is thought to be multidimensional, with "anxiety" representing one dimension. Dissecting emotional dimensions in animal models an essential prerequisite for investigating the neurobiological mechanisms that underlie anxiety. The authors used factor analysis investigate normal rats and bred either high or low anxiety-related behavior. Hyperanxious were reduced elevated plus-maze by selection pressure, a modified hole board test revealed dissection of their emotionality precisely defined dimensions. This enabled clear differentiation from other including risk assessment behavior exploration. Factors extracted analyzing data multiple-test battery corresponded particular characteristics rather than approach might help develop specific treatment strategies anxiety disorders.
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sci-hub.se 参考文章(29)
R.M Escorihuela, A Fernández-Teruel, L Gil, R Aguilar, A Tobeña, P Driscoll, Inbred Roman High- and Low-Avoidance Rats: Differences in Anxiety, Novelty-Seeking, and Shuttlebox Behaviors Physiology & Behavior. ,vol. 67, pp. 19- 26 ,(1999) , 10.1016/S0031-9384(99)00064-5
Arjun Sahgal, Behavioural neuroscience : a practical approach IRL Press. ,(1993)
Ann E. Kelley, Locomotor activity and exploration Techniques in The Behavioral and Neural Sciences. ,vol. 10, pp. 499- 518 ,(1993) , 10.1016/B978-0-444-81444-9.50024-9
Nathalie Castanon, Fernando Perez-Diaz, Pierre Mormède, GENETIC ANALYSIS OF THE RELATIONSHIPS BETWEEN BEHAVIORAL AND NEUROENDOCRINE TRAITS IN ROMAN HIGH AND LOW AVOIDANCE RAT LINES Behavior Genetics. ,vol. 25, pp. 371- 384 ,(1995) , 10.1007/BF02197288
Catherine Belzung, Gilles Le Pape, Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety. Physiology & Behavior. ,vol. 56, pp. 623- 628 ,(1994) , 10.1016/0031-9384(94)90311-5
Jeffrey B. Rosen, Jay Schulkin, From normal fear to pathological anxiety Psychological Review. ,vol. 105, pp. 325- 350 ,(1998) , 10.1037/0033-295X.105.2.325
JOHN L FALK, None, Physiology and Behavior. Psyccritiques. ,vol. 18, ,(1973) , 10.1037/0011818
Gudrun Liebsch, Astrid CE Linthorst, Inga D Neumann, Johannes MHM Reul, Florian Holsboer, Rainer Landgraf, None, Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior Neuropsychopharmacology. ,vol. 19, pp. 381- 396 ,(1998) , 10.1016/S0893-133X(98)00042-6
F. Ohl, F. Holsboer, R. Landgraf, The modified hole board as a differential screen for behavior in rodents Behavior Research Methods, Instruments, & Computers. ,vol. 33, pp. 392- 397 ,(2001) , 10.3758/BF03195393
Y Clement, Biological bases of anxiety. Neuroscience & Biobehavioral Reviews. ,vol. 22, pp. 623- 633 ,(1998) , 10.1016/S0149-7634(97)00058-4