Systems and methods for optical detection of lipofuscin concentrations in a subject's eye

作者: Werner Gellermann , Mohsen Sharifzadeh

DOI:

关键词:

摘要: A method for optical detection of lipofuscin concentrations in the retina is described. subject's eye exposed to a light source. Light emitted from detected. Levels are determined light. system The includes source generate an detector communication with configured detect eye. computing device electronic included determine levels

参考文章(19)
Hayasaka S, Aging changes in lipofuscin, lysosomes and melanin in the macular area of human retina and choroid. Japanese Journal of Ophthalmology. ,vol. 33, pp. 36- 42 ,(1989)
Janet R. Sparrow, Koji Nakanishi, Craig A. Parish, Masaru Hashimoto, A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 2988- 2995 ,(1999)
François C. Delori, C. Kathleen Dorey, Douglas G. Goger, Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Investigative Ophthalmology & Visual Science. ,vol. 42, pp. 1855- 1866 ,(2001)
Janet R. Sparrow, Koji Nakanishi, Craig A. Parish, The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 1981- 1989 ,(2000)
Mohsen Sharifzadeh, Werner Gellerman, Imaging of macular pigment distributions ,(2009)
O Arend, J J Weiter, F C Delori, C K Dorey, G Staurenghi, D G Goger, In Vivo Fluorescence of the Ocular Fundus Exhibits Retinal Pigment Epithelium Lipofuscin Characteristics Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 718- 729 ,(1995)
John J. Weiter, Mark R. Fleckner, Francois C. Delori, C. Kathleen Dorey, Douglas G. Goger, Autofluorescence distribution associated with drusen in age-related macular degeneration. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 496- 504 ,(2000)
Richard F Spaide, Fundus autofluorescence and age-related macular degeneration. Ophthalmology. ,vol. 110, pp. 392- 399 ,(2003) , 10.1016/S0161-6420(02)01756-6