Clinicopathologic analysis of microscopic extension in lung adenocarcinoma: defining clinical target volume for radiotherapy.
作者： Inga S. Grills , Dwight L. Fitch , Neal S. Goldstein , Di Yan , Gary W. Chmielewski
DOI: 10.1016/J.IJROBP.2007.03.023
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摘要: Purpose To determine the gross tumor volume (GTV) to clinical target margin for non–small-cell lung cancer treatment planning. Methods A total of 35 patients with Stage T1N0 adenocarcinoma underwent wedge resection plus immediate lobectomy. The size and microscopic extension distance beyond were measured. nuclear grade percentage bronchoalveolar features analyzed association extension. dimensions measured on a computed tomography (CT) scan (lung mediastinal windows) compared pathologic dimensions. potential coverage two different stereotactic radiotherapy regimens was evaluated. Results mean 7.2 mm varied according (10.1, 7.0, 3.5 Grade 1 3, respectively, p Conclusion For adenocarcinomas, GTV should be contoured using CT windows. Although based windows would underestimate by only 1.2 average case, expansion required cover in 90% cases could as large 9 mm, although considerably smaller high-grade tumors. Fractionation significantly affects dosimetric
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James A. Hayman, Mary K. Martel, Randall K. Ten Haken, Daniel P. Normolle, Robert F. Todd, J. Fred Littles, Molly A. Sullivan, Peter W. Possert, Andrew T. Turrisi, Allen S. Lichter, Dose Escalation in Non–Small-Cell Lung Cancer Using Three-Dimensional Conformal Radiation Therapy: Update of a Phase I Trial Journal of Clinical Oncology. ,vol. 19, pp. 127- 136 ,(2001) , 10.1200/JCO.2001.19.1.127
Z-G Yang, S Sone, F Li, S Takashima, Y Maruyama, T Honda, M Hasegawa, Visibility of small peripheral lung cancers on chest radiographs: influence of densitometric parameters, CT values and tumour type. British Journal of Radiology. ,vol. 74, pp. 32- 41 ,(2001) , 10.1259/BJR.74.877.740032
Hiroshi Onishi, Kengo Kuriyama, Takafumi Komiyama, Shiho Tanaka, Naoki Sano, Kan Marino, Satoshi Ikenaga, Tsutomu Araki, Minoru Uematsu, Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner Lung Cancer. ,vol. 45, pp. 45- 55 ,(2004) , 10.1016/J.LUNGCAN.2004.01.004
Philippe Giraud, Sabine Elles, Sylvie Helfre, Yann De Rycke, Vincent Servois, Marie-France Carette, Claude Alzieu, Pierre-Yves Bondiau, Bernard Dubray, Emmanuel Touboul, Martin Housset, Jean-Claude Rosenwald, Jean-Marc Cosset, Conformal radiotherapy for lung cancer: different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists Radiotherapy and Oncology. ,vol. 62, pp. 27- 36 ,(2002) , 10.1016/S0167-8140(01)00444-3
Jack F. Fowler, Wolfgang A. Tomé, John D. Fenwick, Minesh P. Mehta, A challenge to traditional radiation oncology. International Journal of Radiation Oncology Biology Physics. ,vol. 60, pp. 1241- 1256 ,(2004) , 10.1016/J.IJROBP.2004.07.691
Hiroshi Onishi, Tsutomu Araki, Hiroki Shirato, Yasushi Nagata, Masahiro Hiraoka, Kotaro Gomi, Takashi Yamashita, Yuzuru Niibe, Katsuyuki Karasawa, Kazushige Hayakawa, Yoshihiro Takai, Tomoki Kimura, Yutaka Hirokawa, Atsuya Takeda, Atsushi Ouchi, Masato Hareyama, Masaki Kokubo, Ryusuke Hara, Jun Itami, Kazunari Yamada, Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer. ,vol. 101, pp. 1623- 1631 ,(2004) , 10.1002/CNCR.20539
Robert Timmerman, Lech Papiez, Ronald McGarry, Laura Likes, Colleen DesRosiers, Stephanie Frost, Mark Williams, Extracranial Stereotactic Radioablation*: Results of a Phase I Study in Medically Inoperable Stage I Non-small Cell Lung Cancer Chest. ,vol. 124, pp. 1946- 1955 ,(2003) , 10.1378/CHEST.124.5.1946
Y. Borghero, T. Guerrero, J. Noyola-Martinez, J. Cox, C. Stevens, Z. Liao, M. Jeter, J. Chang, K. Sanders, R. Komaki, Interobserver Variability in Non-Small Cell Lung Cancer Target Delineation Among Thoracic Radiation Oncologists International Journal of Radiation Oncology Biology Physics. ,vol. 63, ,(2005) , 10.1016/J.IJROBP.2005.07.691
Minoru Uematsu, Akira Shioda, Kazuhiko Tahara, Toshiharu Fukui, Fuyumi Yamamoto, Gentaro Tsumatori, Yuichi Ozeki, Teruhiro Aoki, Masazumi Watanabe, Shoichi Kusano, Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients: a preliminary experience Cancer. ,vol. 82, pp. 1062- 1070 ,(1998) , 10.1002/(SICI)1097-0142(19980315)82:6<1062::AID-CNCR8>3.0.CO;2-G
Kenneth E. Rosenzweig, Jana L. Fox, Ellen Yorke, Howard Amols, Andrew Jackson, Valerie Rusch, Mark G. Kris, Clif C. Ling, Steven A. Leibel, Results of a phase I dose-escalation study using three-dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma. Cancer. ,vol. 103, pp. 2118- 2127 ,(2005) , 10.1002/CNCR.21007