Method for docetaxel synthesis
作者： Nicholas J. Sisti , Charles S. Swindell
DOI:
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摘要: A method of producing docetaxel comprises the esterification C7, C10 di-CBZ 10-deacetyl baccatin III and an N-CBZ C2'-protected 3-phenyl isoserine side chain wherein C2' is protected by a hydrogenatable benyl-type protecting group. The carbobenzyloxy groups are then replaced with hydrogen group at C3' nitrogen site t-butoxycarbonyl. Finally, resulting compound deprotected replacing benzyl-type to produce docetaxel. preferably employs excess, such as six equivalents, for each equivalent III. Benzyloxymethyl preferred C2'.
google.co.in 参考文章(24)
Yukio East Paul Dirac Drive Suzuki, Robert A. East Paul Dirac Drive Holton, Seocchan East Paul Dirac Drive Kim, Process for the preparation of baccatin iii analogs bearing new c2 and c4 functional groups ,(1994)
Alain Commercon, Elie Fouque, Eric Didier, Process for the preparation of taxane derivatives ,(1993)
Robert A Holton, Method for preparation of taxol ,(1990)
Francoise Gueritte-Voegelein, Michel Colin, Daniel Guenard, Pierre Potier, Process for preparing derivatives of baccatine III and of 10-deacetyl baccatine III ,(1989)
Koppaka V. Rao, Process for the preparation of taxol and 10-deacetyltaxol ,(1993)
Francoise Gueritte-Voegelein, Michel Colin, Daniel Guenard, Pierre Potier, Taxol derivatives, their preparation and pharmaceutical compositions containing them ,(1987)
Lynn G. Darbie, Qun Y. Zheng, Christopher K. Murray, Selective process for the deacylation and deacetylation of taxol and taxanes ,(1994)
Iwao Ojima, Ezio Bombardelli, Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment ,(1994)
Valentino J Stella, Abraham E Mathew, None, Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof ,(1990)
Elie Fouque, Jean-Manuel Mas, Method of preparing taxane derivatives ,(1993)