Antibody-dependent cellular cytotoxicity in HIV infections.

摘要: ADCC is an important immune effector mechanism against tumor and virus-infected cells that can be destroyed by the combined action of specific antibodies IgG isotype cell surface-associated antigens cells, predominantly NK phenotype. has been shown to function in vivo several systems. With regard HIV, it readily demonstrated vitro viral envelope proteins with serum and/or obtained from HIV-infected subjects. Several studies have titers envy-specific ADCC-mediating decrease sera individuals as infection progresses toward AIDS. The mediate also become functionally compromised these early stages infection, thus depriving host potential benefits this process. Restoration process infected administration competent (in expanded lymphokine-ac...