Synthesis of [2‐(Trimethylsilyl)ethynyl]pyrazoles Based on Bis(trimethylsilyl)acetylene and Arylacetyl Chlorides
作者： Alena S. Pankova , Pavel R. Golubev , Ivan V. Ananyev , Mikhail A. Kuznetsov
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摘要: A practical approach to the synthesis of [2-(trimethylsilyl)ethynyl]pyrazoles was developed through condensation hydrazines with enynones that are easily accessible frombis(trimethylsilyl)acetylene and arylacetyl chlorides. Optimized conditions for reactions monoarylhydrazines permit chemoselective formation 5-alkynylpyrazoles in high yields (48–94 %). When monoalkylhydrazines or parent hydrazine is used, mixtures 3- formed 73–79 % yields. The method uses inexpensive starting materials can be applied a variety substrates, which makes it convenient alkynylpyrazoles.
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