Polymer nanostructures synthesized by controlled living polymerization for tumor-targeted drug delivery.

摘要: The development of drug delivery systems based on well-defined polymer nanostructures could lead to significant improvements in the treatment cancer. design these therapeutic nanosystems must account for numerous systemic and circulation obstacles as well specific pathophysiology tumor. Nanoparticle size surface charge also be carefully selected order maintain long times, allow tumor penetration, avoid clearance by reticuloendothelial system (RES). Targeting ligands such vitamins, peptides, antibodies can improve accumulation nanoparticle-based therapies tissue but optimized intratumoral penetration. In this review, we will highlight factors influencing nanoparticle modern controlled "living" polymerization techniques (e.g. ATRP, RAFT, ROMP) that are leading creation sophisticated new architectures with discrete spatially-defined functional modules. These innovative materials star polymers, brushes, macrocyclic hyperbranched polymers) combine many desirable properties traditional while substantially reducing or eliminating need complex formulations.