Effect on intelligence of relaxing the low phenylalanine diet in phenylketonuria.

摘要: A total of 599 children with phenylketonuria, who had been treated early, were followed up prospectively in order to examine the association between intellectual progress from 4 14 years age and control phenylalanine concentrations. The rose around 400 mumol/l during first four above 900 by 12 years. divided into two cohorts: cohort I comprised 224 born United Kingdom 1964 1971 II 375 1972 1978. In a previous study it was shown that these already mean intelligence quotient (IQ) over half standard deviation below general population norms, IQ fell linearly as average concentrations rose. Multiple regression used estimate size associations at later ages periods assessments, after controlling for control, social class, type factors relating diagnosis early management. For each 300 rise those aged 5 8 4-6 points. This compared 7-10 point fall similar phenylalanine. After disappeared but persisted significant 10 age, although smaller than