The cell biology of vision

作者: Ching-Hwa Sung , Jen-Zen Chuang

DOI: 10.1083/JCB.201006020

关键词:

摘要: Humans possess the remarkable ability to perceive color, shape, and motion, and to differentiate between light intensities varied by over nine orders of magnitude. Phototransduction—the process in which absorbed photons are converted into electrical responses—is the first stage of visual processing, and occurs in the outer segment, the light-sensing organelle of the photoreceptor cell. Studies of genes linked to human inherited blindness have been crucial to understanding the biogenesis of the outer segment and membrane-trafficking of photoreceptors.

参考文章(107)
Christine Insinna, Narendra Pathak, Brian Perkins, Iain Drummond, Joseph C. Besharse, The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. Developmental Biology. ,vol. 316, pp. 160- 170 ,(2008) , 10.1016/J.YDBIO.2008.01.025
Alan M. Laties, Dean Bok, Paul Liebman, Procion yellow: a marker dye for outer segment disc patency and for rod renewal. Experimental Eye Research. ,vol. 23, pp. 139- 148 ,(1976) , 10.1016/0014-4835(76)90197-4
K. Kizhatil, S. A. Baker, V. Y. Arshavsky, V. Bennett, Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia. Science. ,vol. 323, pp. 1614- 1617 ,(2009) , 10.1126/SCIENCE.1169789
Qin Liu, Arkady Lyubarsky, Jason H. Skalet, Edward N. Pugh, Eric A. Pierce, RP1 Is Required for the Correct Stacking of Outer Segment Discs Investigative Ophthalmology & Visual Science. ,vol. 44, pp. 4171- 4183 ,(2003) , 10.1167/IOVS.03-0410
Jiro Usukura, Shuichi Obata, Morphogenesis of photoreceptor outer segments in retinal development Progress in Retinal and Eye Research. ,vol. 15, pp. 113- 125 ,(1995) , 10.1016/1350-9462(95)00006-2
D J Roof, J E Heuser, Surfaces of rod photoreceptor disk membranes: integral membrane components. Journal of Cell Biology. ,vol. 95, pp. 487- 500 ,(1982) , 10.1083/JCB.95.2.487
Xiao-Hong Wen, Lixin Shen, Richard S. Brush, Norman Michaud, Muayyad R. Al-Ubaidi, Vsevolod V. Gurevich, Heidi E. Hamm, Janis Lem, Emmanuele DiBenedetto, Robert E. Anderson, Clint L. Makino, Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophysical Journal. ,vol. 96, pp. 939- 950 ,(2009) , 10.1016/J.BPJ.2008.10.016
Geoff Clarke, Andrew F.X. Goldberg, Danka Vidgen, Leslie Collins, Lynda Ploder, Lois Schwarz, Laurie L. Molday, Janet Rossant, Ágoston Szél, Robert S. Molday, David G. Birch, Roderick R. McInnes, Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Nature Genetics. ,vol. 25, pp. 67- 73 ,(2000) , 10.1038/75621
M. Adamian, M. Grynberg, A. Godzik, T. Li, Y. Zhao, D.-H. Hong, B. Pawlyk, G. Yue, The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: Subserving RPGR function and participating in disk morphogenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 3965- 3970 ,(2003) , 10.1073/PNAS.0637349100