Synthesis of 2-amino-6,7,8,9-tetrahydro-6-phenethyl-3H-pyrimido[4,5-e][1,4]diazepin-4(5H)-one: a model for a potential pyrimido[4,5-e][1,4]diazepine-based folate anti-tumor agent

作者: Austin W. Gann , Partha S. Ray

DOI: 10.1515/HC-2015-0216

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参考文章(4)
Samuel W. Baldwin, Archie Tse, Lynn S. Gossett, Edward C. Taylor, Andre Rosowsky, Chuan Shih, Richard G. Moran, Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase Biochemistry. ,vol. 30, pp. 1997- 2006 ,(1991) , 10.1021/BI00221A037
Edward C. Taylor, James E. Dowling, Synthesis of a pyrimido[4,5-b]azepine analog of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF) Bioorganic & Medicinal Chemistry Letters. ,vol. 7, pp. 453- 456 ,(1997) , 10.1016/S0960-894X(97)00041-3
Mark W. Read, Michael L. Miller, Partha S. Ray, Synthesis of acid and two of its conformationally-restricted analogs Tetrahedron. ,vol. 55, pp. 373- 392 ,(1999) , 10.1016/S0040-4020(98)01060-6
Chi-Huey Wong, Louis Provencher, John A. Porco, Sang-Hun Jung, Yi-Fong Wang, Lihren Chen, Ruo Wang, Darryl H. Steensma, Synthesis and Evaluation of Homoaza Sugars as Glycosidase Inhibitors Journal of Organic Chemistry. ,vol. 60, pp. 1492- 1501 ,(1995) , 10.1021/JO00111A007