Genomic architecture of pharmacological efficacy and adverse events

摘要: The pharmacokinetic and pharmacodynamic disciplines address pharmacological traits, including efficacy adverse events. Pharmacogenomics studies have identified pervasive genetic effects on treatment outcomes, resulting in the development of biomarkers for optimization drug therapy. Pharmacogenomics-based tests are already being applied clinical decision making. However, despite substantial progress identifying etiology response, current biomarker panels still largely rely single gene with a large portion remaining to be discovered. Future research must account combined multiple variants, incorporate pathway-based approaches, explore gene-gene interactions nonprotein coding functional extend across ancestral populations, prioritize laboratory characterization molecular mechanisms. Because factors can play key role accurate capturing main determining outcomes potential improving individual care.