Molecular cloning of bovine class I MHC cDNA.

摘要: Two cDNA cloned from a Hereford cow B cell line (BL-3) have allowed the determination of complete coding region for two class I molecules encoded by bovine MHC (BoLA). The predicted protein sequences all features expected expressed that present peptide Ag to cytotoxic T cells. Comparison with other species strongly suggests these are derived different genes and provides evidence existence second BoLA locus. proteins show greater similarity HLA than H-2 molecules, correlating cross-reactions W6/32 murine anti-HLA-A,B,C mAb molecules. basis epitope preferential association H chains beta 2-m is examined.