Transient hyperammonemia in seizures: a prospective study.

摘要: Summary Purpose:  To investigate the incidence and duration of transient hyperammonemia in seizures to verify significant confounders related seizures. Methods:  One hundred twenty-one noncirrhotic adult patients with admitted emergency department were enrolled study. Laboratory examination was performed, including plasma ammonia level assessment. In addition, basic parameters, underlying systemic diseases, seizure-related conditions assessed. The classified into a group on arrival without, order compare adverse events that occurred during 9-month period. Key Findings:  67.77%. Plasma levels generalized tonic–clonic (GTC) significantly higher than those non-GTC seizure (median 174.5 vs. 47 μg/dl; proportion 76.5% 21.1%; p < 0.001). Median decreased spontaneously from 250 54 μg/dl (p < 0.00001) an average interval 466.79 min. GTC (p < 0.0001), male gender bicarbonate diabetes (p =  0.0139), alcohol-related (p = 0.0002) factors associated arrival. No differences admission rates or mortalities found between two groups. Significance:  presence is seizures, gender, bicarbonate, diabetes, seizures. appropriate period study following event within 8 h. Because these phenomena are self-limited, ammonia-lowering management not necessary. Hyperammonemia necessarily outcomes.