Chapter 8 A novel rotational behavior model for assessing the restructuring of striatal dopamine effector systems: are transplants sensitive to peripherally acting drugs?

摘要: Publisher Summary This chapter discusses the effects on apomorphine-induced turning behavior of rat fetal striatal tissue transplants into lesioned striatum, and determines whether grafts might also possess a non-intact blood-brain barrier permit entry drugs brain, which normally do not penetrate barrier, therefore, are without central actions. The data presented in may indicate that transplanted material possesses similar pharmacological properties as original host tissue, is capable functionally restructuring damage to complex neurochemical system. Domperidone, dopamine receptor antagonist, does readily cross bloodbrain significantly attenuated behavioral apomorphine rats, had received bilateral unlesioned striata prior challenge with apomorphine. Thus, appeared allow access brain drug, acts periphery, it suggested other therapeutic agents be allowed site-selective via tissue.