Tissue Distribution of Methylcobalamin in Rats Fed Amino Acid-Defined, Methyl-Deficient Diets

摘要: Total cobalamin and methylcobalamin levels were determined in tissues of male F344 rats fed a complete, amino acid-defined diet or deficient methionine, choline and/or cyanocobalamin. the complete (picograms/milligram tissue +/- SEM): liver, 67 13; kidneys, 738 133; spleen, 23 2; adrenals, 268 36. Corresponding were: 1.6 0.5; 107.6 22.2; 0.3 0.1; 26.9 5.3; these values represent 2.4, 14.5, 1.4 9.7%, respectively, total levels. all studied altered by deprivation alone conjunction with methionine deprivation. Methylcobalamin more resistant to dietary alteration. Regardless presence absence diet, always decreased proportion liver. Kidney methylcobalamin, like those cobalamin, removal from methyl-deficient diets. The results demonstrate that exert quite different effects on cobalamins rats.