Antioxidant properties of Taraxacum officinale fruit extract are involved in the protective effect against cellular death induced by sodium nitroprusside in brain of rats.
作者： Dirleise Colle , Letícia Priscilla Arantes , Ricardo Rauber , Sérgio Edgar Campos de Mattos , João Batista Teixeira da Rocha
DOI: 10.3109/13880209.2011.641981
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摘要: Context: Taraxacum officinale Weber (Asteraceae), known as dandelion, is used for medicinal purposes due to its choleretic, diuretic, antitumor, antioxidant, antiinflammatory, and hepatoprotective properties.Objective: We sought investigate the protective activity of T. fruit extract against sodium nitroprusside (SNP)-induced decreased cellular viability increased lipid peroxidation in cortex, hippocampus, striatum rats vitro. To explain mechanism extract’s antioxidant activity, putative scavenger activities NO˙, DPPH˙, OH˙, H2O2 were determined.Methods: Slices treated with 50 μM SNP ethanolic (1–20 µg/mL) determine by MTT reduction assay. Lipid was measure cortical, hippocampal striatal slices incubates (5 µM) µg/mL). also determined ex...
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