The impact of high-intensity interval training exercise on breast cancer survivors: a pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems

摘要: Cardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim this study was to explore impact exercise intensity on aerobic fitness and autonomic cardiac regulation (heart rate variability (HRV)) salivary biomarkers stress systems (HPA-axis, cortisol; sympathetic nervous system, α-amylase) mucosal immunity (secretory(s)-IgA), markers increased risk CVD Participants were randomly assigned to; 1) high interval training (HIIT); 2) moderate-intensity, continuous (CMIT); or 3) a wait-list control (CON) for 12-week (36 session) stationary cycling intervention. Cardiorespiratory (VO2peak), resting HRV measured at baseline 2–4 d pre-intervention post last session. Seventeen participants included (62 ± 8 years, HIIT; n = 6, CMIT; n = 5, CON; n = 6). A significant improvement (p ≤ 0.05) observed VO2peak HIIT group; 19.3% (B = 3.98, 95%CI = [1.89; 4.02]) non-significant increase CMIT 5.6% (B = 1.96, 95%CI = [− 0.11; 4.03]), compared with 2.6% (B = − 0.64, 95%CI = [− 2.10; 0.82]) decrease CON group. Post intervention improvements vagal activity (log (ln)LF/HF, LnRMSSD) system (α-amylase waking response) occurred individuals exhibiting outlying (> 95% CI) levels general population. High improved cardiovascular survivors regulation, (stress) responses some individuals. High-intensity safe effective participate promising results as time efficient improve physical health stress, reducing risk. This pilot retrospectively registered through Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12620000684921 .