Widespread Monoallelic Expression on Human Autosomes

摘要: Monoallelic expression with random choice between the maternal and paternal alleles defines an unusual class of genes comprising X-inactivated a few autosomal gene families. Using genome-wide approach, we assessed allele-specific transcription about 4000 human in clonal cell lines found that more than 300 were subject to monoallelic expression. For majority genes, also observed some displaying biallelic Clonal reflect independent express maternal, paternal, or both for each these genes. This can lead differences expressed protein sequence levels Unexpectedly widespread suggests mechanism generates diversity individual cells their descendants.