The transcription factor of the Hippo signaling pathway, LmSd, regulates wing development in Locusta migratoria.
作者： Hong Yin , Xiaohong Zhang , Daochuan Zhang , Ziyang Zhang , Zhixing Liu
DOI: 10.1016/J.IJBIOMAC.2021.02.174
关键词:
摘要: Scalloped (Sd) is transcription factor that regulates cell proliferation and organ growth in the Hippo pathway. In present research, LmSd was identified characterized, found to encode an N-terminal TEA domain a C-terminal YBD domain. qRT-PCR showed level highest fifth-instar nymphs very little expressed embryos. Tissue-specific analyses highly wing. Immunohistochemistry indicated abundant head, prothorax, legs during embryonic development. dsRNA injection resulted significantly down-regulated protein expression levels compared with dsGFP injection. Gene silencing of deformed wings were curved, wrinkled, failed fully expand. Approximately 40% had wing pads not able close normally molting from into adults. After LmSd, division genes suppressed apoptosis up-regulated. Our results reveal plays important role formation development by controlling inhibiting apoptosis.
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