Genotypic and Phylogenetic Insights on Prevention of the Spread of HIV-1 and Drug Resistance in "Real-World" Settings

作者: Bluma Brenner , Ruxandra-Ilinca Ibanescu , Isabelle Hardy , Michel Roger

DOI: 10.3390/V10010010

关键词:

摘要: HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral societal factors. Phylogenetics analyses large sequence datasets from national resistance testing programs reveal the evolutionary interrelationships viral strains implicated in dynamic different regional settings. Viral phylogenetics can be combined demographic information gain insights on epidemiological processes shaping transmission networks at population-level. Drug also emergent mutational pathways leading 23 antiretroviral drugs used HIV-1 management low-, middle- high-income This article describes how genotypic phylogenetic Quebec elsewhere provide critical resistance, Cumulative findings optimize public health strategies tackle challenges "real-world"

参考文章(96)
Bluma G. Brenner, Matthew Lowe, Daniela Moisi, Isabelle Hardy, Simon Gagnon, Hugues Charest, Jean Guy Baril, Mark A. Wainberg, Michel Roger, Subtype diversity associated with the development of HIV-1 resistance to integrase inhibitors. Journal of Medical Virology. ,vol. 83, pp. 751- 759 ,(2011) , 10.1002/JMV.22047
François Raffi, Anita Rachlis, Cynthia Brinson, Keikawus Arasteh, Miguel Górgolas, Clare Brennan, Keith Pappa, Steve Almond, Catherine Granier, W. Garrett Nichols, Robert Liam Cuffe, Joseph Eron Jr, Sharon Walmsley, Dolutegravir efficacy at 48 weeks in key subgroups of treatment-naive HIV-infected individuals in three randomized trials AIDS. ,vol. 29, pp. 167- 174 ,(2015) , 10.1097/QAD.0000000000000519
Sharon L Walmsley, Antonio Antela, Nathan Clumeck, Dan Duiculescu, Andrea Eberhard, Felix Gutiérrez, Laurent Hocqueloux, Franco Maggiolo, Uriel Sandkovsky, Catherine Granier, Keith Pappa, Brian Wynne, Sherene Min, Garrett Nichols, None, Dolutegravir plus Abacavir–Lamivudine for the Treatment of HIV-1 Infection The New England Journal of Medicine. ,vol. 369, pp. 1807- 1818 ,(2013) , 10.1056/NEJMOA1215541
Richard J Lessells, , Katharine E Stott, Justen Manasa, Kevindra K Naidu, Andrew Skingsley, Theresa Rossouw, Tulio de Oliveira, Implementing antiretroviral resistance testing in a primary health care HIV treatment programme in rural KwaZulu-Natal, South Africa: early experiences, achievements and challenges BMC Health Services Research. ,vol. 14, pp. 116- 116 ,(2014) , 10.1186/1472-6963-14-116
Rami Kantor, David A Katzenstein, Brad Efron, Ana Patricia Carvalho, Brian Wynhoven, Patricia Cane, John Clarke, Sunee Sirivichayakul, Marcelo A Soares, Joke Snoeck, Candice Pillay, Hagit Rudich, Rosangela Rodrigues, Africa Holguin, Koya Ariyoshi, Maria Belen Bouzas, Pedro Cahn, Wataru Sugiura, Vincent Soriano, Luis F Brigido, Zehava Grossman, Lynn Morris, Anne-Mieke Vandamme, Amilcar Tanuri, Praphan Phanuphak, Jonathan N Weber, Deenan Pillay, P. Richard Harrigan, Ricardo Camacho, Jonathan M Schapiro, Robert W Shafer, Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration. PLOS Medicine. ,vol. 2, pp. 325- 337 ,(2005) , 10.1371/JOURNAL.PMED.0020112
Francesca Ceccherini-Silberstein, Kurt Van Baelen, Daniele Armenia, Maria Trignetti, Evelien Rondelez, Lavinia Fabeni, Fernanda Scopelliti, Michela Pollicita, Liesbeth Van Wesenbeeck, Veerle Van Eygen, Luca Dori, Loredana Sarmati, Stefano Aquaro, Guido Palamara, Massimo Andreoni, Lieven J. Stuyver, Carlo Federico Perno, Secondary Integrase Resistance Mutations Found in HIV-1 Minority Quasispecies in Integrase Therapy-Naive Patients Have Little or No Effect on Susceptibility to Integrase Inhibitors Antimicrobial Agents and Chemotherapy. ,vol. 54, pp. 3938- 3948 ,(2010) , 10.1128/AAC.01720-09
Daniela Bezemer, Ard van Sighem, Vladimir V Lukashov, Lia van der Hoek, Nicole Back, Rob Schuurman, Charles AB Boucher, Eric CJ Claas, Maarten C Boerlijst, Roel A Coutinho, Frank de Wolf, None, Transmission networks of HIV-1 among men having sex with men in the Netherlands. AIDS. ,vol. 24, pp. 271- 282 ,(2010) , 10.1097/QAD.0B013E328333DDEE
Andrew J. Leigh Brown, Samantha J. Lycett, Lucy Weinert, Gareth J. Hughes, Esther Fearnhill, David T. Dunn, Transmission Network Parameters Estimated From HIV Sequences for a Nationwide Epidemic The Journal of Infectious Diseases. ,vol. 204, pp. 1463- 1469 ,(2011) , 10.1093/INFDIS/JIR550
Geoffrey S. Gottlieb, Laura Heath, David C. Nickle, Kim G. Wong, Stephanie E. Leach, Benjamin Jacobs, Surafel Gezahegne, Angélique B. van ’t Wout, Lisa P. Jacobson, Joseph B. Margolick, James I. Mullins, HIV-1 Variation before Seroconversion in Men Who Have Sex with Men: Analysis of Acute/Early HIV Infection in the Multicenter AIDS Cohort Study The Journal of Infectious Diseases. ,vol. 197, pp. 1011- 1015 ,(2008) , 10.1086/529206
Alexandra Jones, Ide Cremin, Fareed Abdullah, John Idoko, Peter Cherutich, Nduku Kilonzo, Helen Rees, Timothy Hallett, Kevin O'Reilly, Florence Koechlin, Bernhard Schwartlander, Barbara de Zalduondo, Susan Kim, Jonathan Jay, Jacqueline Huh, Peter Piot, Mark Dybul, Transformation of HIV from pandemic to low-endemic levels: a public health approach to combination prevention. The Lancet. ,vol. 384, pp. 272- 279 ,(2014) , 10.1016/S0140-6736(13)62230-8