作者: Bluma Brenner , Ruxandra-Ilinca Ibanescu , Isabelle Hardy , Michel Roger
DOI: 10.3390/V10010010
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摘要: HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral societal factors. Phylogenetics analyses large sequence datasets from national resistance testing programs reveal the evolutionary interrelationships viral strains implicated in dynamic different regional settings. Viral phylogenetics can be combined demographic information gain insights on epidemiological processes shaping transmission networks at population-level. Drug also emergent mutational pathways leading 23 antiretroviral drugs used HIV-1 management low-, middle- high-income This article describes how genotypic phylogenetic Quebec elsewhere provide critical resistance, Cumulative findings optimize public health strategies tackle challenges "real-world"