Intravenous administration of diazepam significantly reduces brown fat activity on 18F-FDG PET/CT.

摘要: BACKGROUND Brown adipose tissue (BAT) activity on (18)F-fluorodeoxyglucose (FDG) PET/CT can introduce an undesirable element of complexity when attempting to discern physiologic from more ominous entities. Recent studies have demonstrated several methods reduce BAT FDG uptake. Benzodiazepines, however, yet been proven effective against BAT. METHODS Twenty-five patients with increased uptake were selected retrospectively our database between November 2004 and January 2011. These had asked return a different day for repeat scanning 5mg intravenous diazepam, administered ten minutes prior FDG. Two underwent this procedure second occasion (for follow-up scan at later date), thus resulting in total twenty-seven scans twenty five patients. was recorded using the maximum standardized value (SUVmax). RESULTS The mean basal SUVmax 10.1 ± 4.6 compared 2.8 3.3 post IV diazepam (p < 0.0001). Approximately 89% (24 27) no significant residual activity. three remaining reduction ranging 23-64% following administration. No adverse effects noted. CONCLUSION We observed brown fat para-spinal, cervical, mediastinal, para-adrenal, supra- infra-clavicular regions premedication diazepam. feel that benzodiazepines should be considered pharmacologic option reducing uptake, which turn, will aid distinguishing metabolic pathology.