Involvement of Heparanase in Gastric Cancer Progression and Immunotherapy.
作者： Bo Tang , Shiming Yang
DOI: 10.1007/978-3-030-34521-1_13
关键词:
摘要: Heparanase is upregulated in various tumors, and its expression closely associated with tumor growth, angiogenesis metastasis, which accomplishes this mainly through degrading heparan sulfate releasing heparin-binding growth factors thereby influencing multiple signaling pathways. In addition to enzymatic activity, heparanase can act via non-enzymatic mechanisms that directly regulate signaling. This review focuses on the levels role of gastric cancer, genes regulating cancer. Furthermore, development heparanase-targeted immunotherapy potential application for treating cancer are discussed.
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