作者: Jean Calleja-Agius , Shanthi Muttukrishna , Eric Jauniaux
DOI: 10.1586/EEM.09.4
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摘要: TNF-α is a highly versatile cytokine, playing an important role in both apoptosis and inflammation, which central to reproduction. It belongs the Th1 type of cytokines. Thus, proinflammatory cytokine involved during follicle development ovulation, corpus luteum formation regression cyclic endometrium function. has been postulated be detrimental survival conceptus due human primary villous trophoblast cells, leading miscarriage. However, may have dual early pregnancy. Hormonally regulated uterine mother probably essential for cell invasion, while increased production by maternal macrophages facilitate labor. The current knowledge on its receptors female reproduction described this review.