Role of TNF-α in human female reproduction

作者: Jean Calleja-Agius , Shanthi Muttukrishna , Eric Jauniaux

DOI: 10.1586/EEM.09.4

关键词:

摘要: TNF-α is a highly versatile cytokine, playing an important role in both apoptosis and inflammation, which central to reproduction. It belongs the Th1 type of cytokines. Thus, proinflammatory cytokine involved during follicle development ovulation, corpus luteum formation regression cyclic endometrium function. has been postulated be detrimental survival conceptus due human primary villous trophoblast cells, leading miscarriage. However, may have dual early pregnancy. Hormonally regulated uterine mother probably essential for cell invasion, while increased production by maternal macrophages facilitate labor. The current knowledge on its receptors female reproduction described this review.

参考文章(140)
Haranaka K, Satomi N, Kunii O, Research on the production site of tumor necrosis factor (TNF). The Japanese journal of experimental medicine. ,vol. 51, pp. 317- 322 ,(1981)
M. M. Philippeaux, P. F. Piguet, Expression of tumor necrosis factor-alpha and its mRNA in the endometrial mucosa during the menstrual cycle. American Journal of Pathology. ,vol. 143, pp. 480- 486 ,(1993)
D V Goeddel, G E Nedwin, P E Hass, L P Svedersky, B B Aggarwal, M R Shalaby, P M Peters, R B Herberman, J R Ortaldo, T S Bringman, Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes. Journal of Immunology. ,vol. 137, pp. 2592- 2598 ,(1986)
B B Aggarwal, W J Kohr, P E Hass, B Moffat, S A Spencer, W J Henzel, T S Bringman, G E Nedwin, D V Goeddel, R N Harkins, Human tumor necrosis factor: Production, purification, and characterization Journal of Biological Chemistry. ,vol. 260, pp. 2345- 2354 ,(1985) , 10.1016/S0021-9258(18)89560-6
A. Sampson-Johannes, S. Fong, D. Lowe, L. Lin, Hye-Yeng Min, P. Ralph, I. Nakoinz, IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. Journal of Immunology. ,vol. 148, pp. 808- 814 ,(1992)
M L Lohmann-Matthes, T Decker, B Luettig, Evidence for the existence of two forms of membrane tumor necrosis factor: an integral protein and a molecule attached to its receptor. Journal of Immunology. ,vol. 143, pp. 4034- 4038 ,(1989)
H M Han, A A Kolhatkar, M W Marino, K M Manchester, D B Donner, Identification, characterization, and homologous up-regulation of latent (cryptic) receptors for tumor necrosis factor-alpha in rat liver plasma membranes. Journal of Biological Chemistry. ,vol. 265, pp. 18590- 18594 ,(1990) , 10.1016/S0021-9258(17)44792-2
S Sampognaro, L Giannarini, R Manetti, F Annunziato, M G Giudizi, P Parronchi, M P Piccinni, L Beloni, R Biagiotti, C Livi, Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. Journal of Immunology. ,vol. 155, pp. 128- 133 ,(1995)