The Impact of Inherited Thrombophilia on Placental Haemostasis and Adverse Pregnancy Outcomes

摘要: While the last century has seen substantial developments in our understanding of many human diseases, there are still vast gaps knowledge about physiological and pathological processes. This is particularly so obstetrics, where advances care have resulted significant declines both maternal perinatal mortality developed countries. Yet, despite this, conditions such as pre-eclampsia, fetal growth restriction, stillbirth, miscarriage placental abruption remain to a large extent idiopathic. Prediction prevention these complications remains limited, with timely delivery representing only effective treatment strategy cases restriction abruption. will often result premature infant who requires investment community family resources – financial, physical, intellectual emotional develop their full potential. The longer term sequelae adult onset diabetes, hypertension obesity, (Barker et al. 1993) effects prematurity chronic lung disease (Askie 2005) neurodevelopmental impairment (Guellec 2011) represent additional burdens. Any improvements that can be made serious pregnancy disorders, therefore potential impact significantly not on well being, but also well-being future generations. A consistent finding among patients experiencing areas thrombosis histological examination placenta (Salafia 1995a; Salafia 1995b). prompted suggestion disturbances coagulation may contribute aetiology conditions. recognition association between inherited thrombophilias venous thromboembolism sparked interest possibility play role complications. In this review, current state regarding thrombophilia adverse outcome critically examined.