The role of protein tyrosine phosphatases in prostate cancer biology.
作者： Caroline E. Nunes-Xavier , Janire Mingo , José I. López , Rafael Pulido
DOI: 10.1016/J.BBAMCR.2018.06.016
关键词:
摘要: Abstract Prostate cancer (PCa) is the most frequent malignancy in male population of Western countries. Although earlier detection and more active surveillance have improved survival, it still a challenge how to treat advanced cases. Since androgen receptor (AR) AR-related signaling pathways are fundamental growth normal neoplastic prostate cells, targeting synthesis or AR activity constitutes basis current hormonal therapies PCa. However, resistance these treatments develops, both by AR-dependent -independent mechanisms. Thus, alternative therapeutic approaches should be developed target efficiently disease. Protein tyrosine phosphatases (PTPs) direct regulators protein- residue-specific phosphotyrosine (pTyr) content dysregulation cellular Tyr phosphorylation/dephosphorylation balance major driving event cancer, including Here, we review knowledge on role classical PTPs growth, differentiation, survival epithelial their potential as important players targets for modulation
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