摘要: Publisher Summary This chapter presents a brief historical account of the discoveries opiate receptors and their ligands. It was direct biochemical demonstration stereospecific binding sites that led to discovery endogenous opioid peptides initiated era explosive developments in neuropeptide research. With development vitro assay, it became possible demonstrate wide distribution these receptor throughout central nervous system (CNS) which suggested physiological functions. Moreover, were shown exist all vertebrate species some invertebrates. Their survival evolution so many bears further witness importance organisms possess them, is not likely be result ability bind plant alkaloids. There sufficient circumstantial evidence permit hypothesis CNS endorphins are neurotransmitters or modulators may play important roles pain modulation, addiction, various aspects emotion behavior.
sci-hub.st 参考文章(69)
Donald E. Richardson, Huda Akil, Pain reduction by electrical brain stimulation in man: Part 2: Chronic self-administration in the periventricular gray matter Journal of Neurosurgery. ,vol. 47, pp. 184- 194 ,(1977) , 10.3171/JNS.1977.47.2.0184
R E Huppler, P E Gilbert, W R Martin, J A Thompson, C G Eades, The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. Journal of Pharmacology and Experimental Therapeutics. ,vol. 197, pp. 517- 532 ,(1976)
R. R. Goodman, S. H. Snyder, M. J. Kuhar, W. S. Young, Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 6239- 6243 ,(1980) , 10.1073/PNAS.77.10.6239
E. J. Simon, J. Groth, Kinetics of opiate receptor inactivation by sulfhydryl reagents: evidence for conformational change in presence of sodium ions Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 2404- 2407 ,(1975) , 10.1073/PNAS.72.6.2404
Characterization of opioid receptors in nervous tissue. Proceedings of The Royal Society B: Biological Sciences. ,vol. 210, pp. 113- 122 ,(1980) , 10.1098/RSPB.1980.0122
C. B. Pert, S. H. Snyder, Opiate Receptor: Demonstration in Nervous Tissue Science. ,vol. 179, pp. 1011- 1014 ,(1973) , 10.1126/SCIENCE.179.4077.1011
Jacob M. Hiller, Eric J. Simon, Stanley M. Crain, Edith R. Peterson, Opiate receptors in cultures of fetal mouse dorsal root ganglia (DRG) and spinal cord: predominance in DRG neurites. Brain Research. ,vol. 145, pp. 396- 400 ,(1978) , 10.1016/0006-8993(78)90875-2
Carole Lamotte, Candace B. Pert, Solomon H. Snyder, Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section. Brain Research. ,vol. 112, pp. 407- 412 ,(1976) , 10.1016/0006-8993(76)90296-1
E. J. Simon, J. M. Hiller, I. Edelman, Stereospecific binding of the potent narcotic analgesic (3H) Etorphine to rat-brain homogenate. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 1947- 1949 ,(1973) , 10.1073/PNAS.70.7.1947
Alistair D. Corbett, Roberto P. Sosa, Alexander t. McKnight, Hans W. Kosterlitz, Effects of electrical stimulation on teh enkephalinsin guinea-pig small intestine European Journal of Pharmacology. ,vol. 65, pp. 113- 117 ,(1980) , 10.1016/0014-2999(80)90219-8