Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria.

摘要: Increased osteoclastic bone resorption plays a central role in the pathogenesis of many diseases. Ganoderma lucidum is known for medicinal effects such as anti-inflammatory and anti-bone activities. In this study, we investigated inhibitory ganoderic acids isolated from G. on differentiation using RAW264 cells vitro. A carbonyl C7 essential to elicit inhibition osteoclast differentiation.