Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS, and Restraining the Tumor Microenvironment
作者： Emily Chia Yu Su , Jeak Ling Ding , Shu Chun Chang , Yen Kuang Lin , Bo Xiang Zhang
DOI: 10.3390/IJMS22041626
关键词:
摘要: … Hiltonol is the structurally improved and more stable form of polyI:C [10], and our results showed that Hiltonol … Furthermore, treatment with 20 μg/mL Hiltonol +++ for 72 h exerted greater …
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Zhong Cai, Qiuyan Chen, Jun Chen, Yi Lu, Guozhi Xiao, Zhihao Wu, Qinghua Zhou, Jian Zhang, Monocyte chemotactic protein 1 promotes lung cancer-induced bone resorptive lesions in vivo. Neoplasia. ,vol. 11, pp. 228- 236 ,(2009) , 10.1593/NEO.81282
Glen N. Barber, Judy Tomita, Ara G. Hovanessian, Eliane Meurs, Michael G. Katze, Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli. Biochemistry. ,vol. 30, pp. 10356- 10361 ,(1991) , 10.1021/BI00106A038
Li-Chung Hsu, Jin Mo Park, Kezhong Zhang, Jun-Li Luo, Shin Maeda, Randal J. Kaufman, Lars Eckmann, Donald G. Guiney, Michael Karin, The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4 Nature. ,vol. 428, pp. 341- 345 ,(2004) , 10.1038/NATURE02405
Mikkel Søes Ibsen, Hans Henrik Gad, Line Lykke Andersen, Veit Hornung, Ilkka Julkunen, Saumendra N. Sarkar, Rune Hartmann, Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling Nucleic Acids Research. ,vol. 43, pp. 5236- 5248 ,(2015) , 10.1093/NAR/GKV389
M. Salazar Andres, B. Levy Hilton, Ondra Steven, Kende Meir, Scherokman Barbara, Brown Douglas, Mena Hernando, Martin Norman, Schwab Karen, Donovan Daniel, Dougherty David, Pulliam Morris, Ippolito Mark, Graves Maria, Brown Herbert, Ommaya Alex, Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study. Neurosurgery. ,vol. 38, pp. 1096- 1104 ,(1996) , 10.1097/00006123-199606000-00006
Saurabh Chattopadhyay, Ganes C. Sen, dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effects. Journal of Interferon and Cytokine Research. ,vol. 34, pp. 427- 436 ,(2014) , 10.1089/JIR.2014.0034
Janani Panneerselvam, Jiankang Jin, Manish Shanker, Jason Lauderdale, Jonathan Bates, Qi Wang, Yan D. Zhao, Stephen J. Archibald, Timothy J. Hubin, Rajagopal Ramesh, IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1/CXCR4 Signaling Axis PLOS ONE. ,vol. 10, pp. e0122439- ,(2015) , 10.1371/JOURNAL.PONE.0122439
Julian R. Molina, Ping Yang, Stephen D. Cassivi, Steven E. Schild, Alex A. Adjei, Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship Mayo Clinic proceedings. Mayo Clinic. ,vol. 83, pp. 584- 594 ,(2008) , 10.4065/83.5.584
Gary Geiss, Ge Jin, Jinjiao Guo, Roger Bumgarner, Michael G. Katze, Ganes C. Sen, A Comprehensive View of Regulation of Gene Expression by Double-stranded RNA-mediated Cell Signaling Journal of Biological Chemistry. ,vol. 276, pp. 30178- 30182 ,(2001) , 10.1074/JBC.C100137200
Paul B Mullan, Alison M Hosey, Niamh E Buckley, Jennifer E Quinn, Richard D Kennedy, Patrick G Johnston, D Paul Harkin, The 2,5 oligoadenylate synthetase/RNaseL pathway is a novel effector of BRCA1- and interferon-gamma-mediated apoptosis. Oncogene. ,vol. 24, pp. 5492- 5501 ,(2005) , 10.1038/SJ.ONC.1208698